ZX782

Description

ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol HBA and appears bright blue under acidic conditions, which can be used for quantitative determination. ZX782 is composed of target protein ligand red part ML-210 HY-100003 , PROTAC linker black part Bromo-PEG2-CH2-Boc HY-141371 and Hty molecule blue part Adamantan-1-ylmethanamine HY-W037848 . The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br HY-161974 , and the activity control of the target protein ligand is Hydroxyl-ML-210 HY-161973 .